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Educational Background
Research Interests
Publications
Grants
Courses Taught
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CURRICULUM VITA
Educational
Background
B.A. in Psychology, State University of New York at Oswego, 1984
Ph.D. in Psychology, Vanderbilt University, 1989
Postdoctoral Training, University of South Carolina 1989-1991
Research Interests
• Behavioral Neuropharmacology
• Discriminative stimulus properties of addictive and psychotropic drugs
• Neuropharmacological actions of addictive drugs
• Substance abuse
Published Research Articles
Poling, A. Morgan, K., Panos, J., Kim, E.,
O'Hare, E., Cleary, J.P., Lesné, S., Ashe, K.H. Porritt, M. and Baker, L.E.
(2008) Oligomers of the amyloid-beta protein disrupt working memory:
confirmation with two behavioral procedures. Behavioural Brain Research.
L.E. Baker, G.D. Searcy, D.M. Pynnonen, and A.D.
Poling (2008) Differentiating the discriminative stimulus effects of gamma-hydroxybutyrate
and ethanol in a three-choice drug discrimination procedure in rats.
Pharmacology, Biochemistry and Behavior. 89(4): 598-607.
Kueh, D., Iwamoto, K., Poling, A. and Baker, L.E.
(2008) Effects of γ-hydroxybutyrate (GHB) and its metabolic precursors on
delayed-matching-to-position performance in rats. Pharmacology,
Biochemistry and Behavior. 89(2): 179-187.
Laraway, S., Snycerski,
S. Baker, L.E. & Poling A.D. (2008) Gamma-hydroxybutyrate (GHB) reduces
accuracy and response rates in rats responding under
fixed-consecutive-number schedules. Pharmacology, Biochemistry and
Behavior.
88 (3):
205-212.
Kueh, D
and Baker, L.E. (2007) Reinforcement schedule effects in rats trained to
discriminate 3,4-methylenedioxymethamphetamine (MDMA) or cocaine.
Psychopharmacology.189:
447-457.
Baker. L.E.,
VanTilburg, T.J., Brandt, A.E. and Poling, A.D. (2005) Discriminative
stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor,
gamma-butyrolactone (GBL) in rats.
Psychopharmacology. 181: 458-466.
Baker,
L.E., Pynnonen, D.M. and Poling, A.D. (2004) Influence of reinforcer
type and route of administration on gamma-hydroxybutyrate discrimination in
rats. Psychopharmacology. 174: 220-227.
Prus, A.J., Baker, L.E. and Meltzer, H.Y. (2004)
Discriminative stimulus properties of 1.25 mg/kg and 5.0 mg/kg doses of
clozapine in rats: examination of the role of dopamine, serotonin and
cholinergic receptor mechanisms. Pharmacology,
Biochemistry and Behavior. 77:
199-208.
Goodwin, A.K.,
Pynnonen, D.M. and Baker, L.E. (2003) Serotonergic-dopaminergic mediation
of MDMA’s discriminative stimulus effects in a three-choice discrimination.
Pharmacology, Biochemistry and Behavior. 74, 987-995.
Goodwin, A. K.,
& Baker, L. E. (2002). An analysis of the utility of
differential outcome procedures in drug discrimination research. Behavioural
Pharmacology, 13, 271-278.
Baker, L. E., & Prus, A. J. (2002).
Reevaluation of PNU-99194A discriminative stimulus effects:
Potentiation by both a D2 antagonist and a D3/D2 agonist. Pharmacology,
Biochemistry and Behavior, 73, 753-758.
Goudie, A. J., Baker, L. E., Smith, J. A., Prus, A. J.,
Svensson K. A., Cortes-Burgos L. A., Wong E. H. F., & Haadsma-Svensson,
S. (2001). Common discriminative stimulus properties in rats of
muscarinic antagonists, clozapine and the D3 preferring antagonist
PNU-99194A: an analysis of possible mechanisms. Behavioural
Pharmacology, 12, 303-15.
Christian, A. C., Goodwin, A. K., & Baker, L.
E. (2001). Antagonism of the discriminative stimulus effects of
(+)-7-OH-DPAT by remoxipride but not by PNU-99194A. Pharmacology
Biochemistry and Behavior, 68, 371-377.
Byrne, T., Baker, L. E., & Poling, A. D. (2000). MDMA and
learning: effects of acute and neurotoxic exposure in the rat. Pharmacology
Biochemistry and Behavior, 66, 501-508.
Goodwin, A. K., & Baker, L. E. (2000). A three-choice drug
discrimination procedure dissociates the discriminative stimulus effects of
MDMA and d-amphetamine. Experimental and Clinical Psychopharmacology,
8, 415-423.
Baker, L. E., Hood, C. A., & Heidema, A. M. (1999).
Assessment of D3 versus D2 receptor modulation of the discriminative
stimulus effects of (+)-7-OH-DPAT in rats. Behavioural
Pharmacology, 10, 717-722.
Garner K. J., & Baker, L. E. (1999). Analysis of D2 and D3
receptor selective ligands in rats trained to discriminate cocaine from
saline. Pharmacology Biochemistry and Behavior, 64, 373-378.
Virden, T. B., & Baker, L. E. (1999). Disruption of the
discriminative stimulus effects of S(+)-3, 4-methylenedioxymethamphetamine
(MDMA) by (±)-MDMA neurotoxicity: protection by fluoxetine. Behavioural
Pharmacology, 10, 195-204..
Baker, L. E., Garner, K. J., Goodwin, A. K., & Svensson, K. A.
(1998). The dopamine D3 receptor antagonist PNU-99194A fails to block
(+)-7-OH-DPAT substitution for d-amphetamine or cocaine. European
Journal of Pharmacology, 358, 101-109.
Franklin, S. R., Baker, L. E., & Svensson K. A. (1998).
Discriminative stimulus properties of the dopamine D3 antagonist
PNU-99194A. Psychopharmacology, 138, 40-46.
Baker, L. E., Virden, T. B., Miller, M. E., & Sullivan, C. L.
(1997). Time course analysis of the discriminative stimulus effects
of the optical isomers of 3,4-methylenedioxymethamphetamine (MDMA). Pharmacology
Biochemistry and Behavior, 58, 505-516.
Baker, L. E., Miller, M. E., & Svensson, K. (1997).
Assessment of the discriminative stimulus effects of the selective dopamine
D3 antagonist PNU-99194A in rats: Comparison to psychostimulants. Behavioral
Pharmacology, 8, 243-252.
Morgan, T. B., & Baker, L. E. (1997). The application of
differential outcomes to a cocaine - saline discrimination procedure. Behavioural
Pharmacology, 8, 1-6.
Baker, L. E., & Taylor M. M. (1997). Assessment of the MDA
and MDMA optical isomers in a stimulant-hallucinogen discrimination. Pharmacology
Biochemistry and Behavior, 57, 737-748.
Baker, L. E., & Makhay, M. M. (1996). Effects of
(+)-fenfluramine on 3,4-methylenedioxy-methamphetamine (MDMA)
discrimination in rats. Pharmacology, Biochemistry and Behavior,
53, 455-461.
Baker, L.E., Broadbent,
J.B. Michael, E.K., Matthews, P.K., Metosh, C.A., Saunders, R.B., West, W.B.
and Appel, J.B. (1995) Assessment of the discriminative stimulus effects of
the optical isomers of ecstasy (3,4‑methylenedioxymethamphetamine; MDMA).
Behavioral Pharmacology. 6: 263-275.
Baker, L.E., Riddle,
E.E., Saunders, R.B., and Appel, J.B. (1993) The role of monoamine uptake in
the discriminative stimulus effects of cocaine and related compounds.
Behavioral Pharmacology. 4: 69-79
Appel, J. B., Baker,
L. E., Barrett, R. L., Broadbent J., Michael, E. K., Riddle, E. E. and Van Groll, B.J.
(1991) The use of drug discrimination in drug abuse research. NIDA
Research Monograph Series. 116: 369-397.
Federally Funded
Grants
GHB: discrimination and effects on learning. R01 grant funded
by the NIH, 2001–2004.
A Three-Lever Discrimination of MDMA and LSD in Rats.
NRSA funded by the NIH for doctoral student Amy Goodwin, 2000–2002.
Dopamine D3 Receptors in Psychostimulant Discrimination.
R03 grant funded by the NIH, 1996-1999.
Intramural Funding
Neurobehavioral Effects of Subchronic Dietary
Lead Exposure in Fisher 344 Rats. 2005-2006.
Web-based Instruction and Multimedia Laboratory
Experiences in Biopsychology. Teaching and Learning with Technology Grant.
2002-2003.
Effects of Acute and Repeated GHB Exposure on
Rat Brain Dopamine Systems Using In Vivo Microdialysis. NeuroJumpstart
Award. 2001-2002.
Courses Taught
Psy 372: Physiological Psychology
Psy 378: Physiological Psychology Laboratory
Psy 526: Human Drug Use and Abuse
Psy 595: History of Psychology
Psy 612: Advanced Physiological Psychology
Psy 613: Behavioral Pharmacology
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