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Educational
Background
Research
Interests
Publications
Grants
Courses Taught
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CURRICULUM VITA
Education
B.A. in Psychology, State
University of New York at Oswego, 1984
Ph.D. in Psychology, Vanderbilt University, 1989
Postdoctoral Training, University of South Carolina 1989-1991
Research Interests
• Behavioral
Neuropharmacology
• Discriminative stimulus properties of addictive and psychotropic
drugs
• Neuropharmacological actions of addictive drugs
• Substance abuse
Published Research
Articles
Baker, L.E., Panos, J.J., Killinger, B.A., Peet, M.M. Bell,
L.M., Haliw, L.A., Walker, S.L. (2009) Comparison of the Discriminative
Stimulus Effects of Salvinorin A and its Derivatives to U69,593 and
U50,488 in Rats. Psychopharmacology. 203 (2): 203-211.
Poling, A. Morgan, K., Panos, J., Kim, E., O'Hare, E.,
Cleary, J.P., Lesné, S., Ashe, K.H. Porritt, M. and Baker, L.E.
(2008) Oligomers of the amyloid-beta protein disrupt working memory:
confirmation with two behavioral procedures. Behavioural Brain
Research.
Baker, L.E., Searcy, G.D., Pynnonen, D.M. and Poling,
A.D. (2008) Differentiating the discriminative stimulus effects of
gamma-hydroxybutyrate and ethanol in a three-choice drug discrimination
procedure in rats. Pharmacology, Biochemistry and Behavior. 89(4):
598-607.
Kueh, D., Iwamoto, K., Poling, A. and Baker, L.E. (2008)
Effects of γ-hydroxybutyrate (GHB) and its metabolic precursors
on delayed-matching-to-position performance in rats. Pharmacology,
Biochemistry and Behavior. 89(2): 179-187.
Laraway,
S., Snycerski, S. Baker, L.E. & Poling A.D. (2008)
Gamma-hydroxybutyrate (GHB) reduces accuracy and response rates in rats
responding under fixed-consecutive-number schedules. Pharmacology,
Biochemistry and Behavior. 88 (3): 205-212.
Kueh, D and Baker, L.E. (2007) Reinforcement schedule effects
in rats trained to discriminate 3,4-methylenedioxymethamphetamine
(MDMA) or cocaine. Psychopharmacology.189: 447-457.
Baker.
L.E., VanTilburg, T.J., Brandt, A.E. and Poling, A.D. (2005)
Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its
metabolic precursor, gamma-butyrolactone (GBL) in rats. Psychopharmacology. 181: 458-466.
Baker,
L.E., Pynnonen, D.M. and Poling, A.D. (2004) Influence of reinforcer
type and route of administration on gamma-hydroxybutyrate
discrimination in rats. Psychopharmacology. 174: 220-227.
Prus, A.J., Baker, L.E.
and Meltzer, H.Y. (2004) Discriminative stimulus properties of 1.25
mg/kg and 5.0 mg/kg doses of clozapine in rats: examination of the role
of dopamine, serotonin and cholinergic receptor mechanisms. Pharmacology,
Biochemistry and Behavior. 77: 199-208.
Goodwin, A.K., Pynnonen,
D.M. and Baker, L.E. (2003) Serotonergic-dopaminergic mediation of
MDMA’s discriminative stimulus effects in a three-choice
discrimination. Pharmacology, Biochemistry and Behavior. 74, 987-995.
Goodwin, A. K., &
Baker, L. E. (2002). An analysis of the utility of
differential outcome procedures in drug discrimination research. Behavioural
Pharmacology, 13, 271-278.
Baker, L. E., & Prus,
A. J. (2002). Reevaluation of PNU-99194A discriminative
stimulus effects: Potentiation by both a D2 antagonist and a
D3/D2 agonist. Pharmacology, Biochemistry and Behavior,
73, 753-758.
Goudie, A. J., Baker, L.
E., Smith, J. A., Prus, A. J., Svensson K. A., Cortes-Burgos L. A.,
Wong E. H. F., & Haadsma-Svensson, S. (2001). Common
discriminative stimulus properties in rats of muscarinic antagonists,
clozapine and the D3 preferring antagonist PNU-99194A: an analysis of
possible mechanisms. Behavioural Pharmacology, 12, 303-15.
Christian, A. C.,
Goodwin, A. K., & Baker, L. E. (2001). Antagonism of
the discriminative stimulus effects of (+)-7-OH-DPAT by remoxipride but
not by PNU-99194A. Pharmacology Biochemistry and Behavior, 68,
371-377.
Byrne, T., Baker, L. E., & Poling, A. D. (2000). MDMA
and learning: effects of acute and neurotoxic exposure in the
rat. Pharmacology Biochemistry and Behavior, 66, 501-508.
Goodwin, A. K., & Baker, L. E. (2000). A three-choice
drug discrimination procedure dissociates the discriminative stimulus
effects of MDMA and d-amphetamine. Experimental and Clinical
Psychopharmacology, 8, 415-423.
Baker,
L. E., Hood, C. A., & Heidema, A. M. (1999). Assessment
of D3 versus D2 receptor modulation of the discriminative stimulus
effects of (+)-7-OH-DPAT in rats. Behavioural Pharmacology,
10, 717-722.
Garner K. J., & Baker, L. E. (1999). Analysis of D2 and D3
receptor selective ligands in rats trained to discriminate cocaine from
saline. Pharmacology Biochemistry and Behavior, 64,
373-378.
Virden, T. B., & Baker, L. E. (1999). Disruption of the
discriminative stimulus effects of S(+)-3,
4-methylenedioxymethamphetamine (MDMA) by (±)-MDMA
neurotoxicity: protection by fluoxetine. Behavioural
Pharmacology, 10, 195-204..
Baker, L. E., Garner, K. J., Goodwin, A. K., & Svensson, K.
A. (1998). The dopamine D3 receptor antagonist PNU-99194A
fails to block (+)-7-OH-DPAT substitution for d-amphetamine or
cocaine. European Journal of Pharmacology, 358, 101-109.
Franklin, S. R., Baker, L. E., & Svensson K. A. (1998).
Discriminative stimulus properties of the dopamine D3 antagonist
PNU-99194A. Psychopharmacology, 138, 40-46.
Baker, L. E., Virden, T. B., Miller, M. E., & Sullivan, C. L.
(1997). Time course analysis of the discriminative stimulus
effects of the optical isomers of 3,4-methylenedioxymethamphetamine
(MDMA). Pharmacology Biochemistry and Behavior, 58,
505-516.
Baker, L. E., Miller, M. E., & Svensson, K. (1997).
Assessment of the discriminative stimulus effects of the selective
dopamine D3 antagonist PNU-99194A in rats: Comparison to
psychostimulants. Behavioral Pharmacology, 8, 243-252.
Morgan, T. B., & Baker, L. E. (1997). The application
of differential outcomes to a cocaine - saline discrimination
procedure. Behavioural Pharmacology, 8, 1-6.
Baker, L. E., & Taylor M. M. (1997). Assessment of the
MDA and MDMA optical isomers in a stimulant-hallucinogen
discrimination. Pharmacology Biochemistry and Behavior,
57, 737-748.
Baker, L. E., & Makhay, M. M. (1996). Effects of
(+)-fenfluramine on 3,4-methylenedioxy-methamphetamine (MDMA)
discrimination in rats. Pharmacology, Biochemistry and
Behavior, 53, 455-461.
Baker,
L.E., Broadbent, J.B. Michael, E.K., Matthews, P.K., Metosh, C.A.,
Saunders, R.B., West, W.B. and Appel, J.B. (1995) Assessment of
the discriminative stimulus effects of the optical isomers of ecstasy
(3,4‑methylenedioxymethamphetamine; MDMA). Behavioral
Pharmacology. 6: 263-275.
Baker,
L.E., Riddle, E.E., Saunders, R.B., and Appel, J.B. (1993) The role of
monoamine uptake in the discriminative stimulus effects of cocaine and
related compounds. Behavioral Pharmacology. 4: 69-79
Appel,
J. B., Baker, L. E.,
Barrett, R. L., Broadbent J., Michael, E. K.,
Riddle, E. E. and Van Groll, B.J. (1991) The use of
drug discrimination in drug abuse research. NIDA Research Monograph
Series. 116: 369-397.
Federally
Funded Grants
GHB: Discrimination and
Effects on Learning. R01 grant funded by the NIH, 2001–2004.
A Three-Lever
Discrimination of MDMA and LSD in Rats. NRSA funded by the NIH for
doctoral student Amy Goodwin, 2000–2002.
Dopamine D3 Receptors in
Psychostimulant Discrimination. R03 grant funded by the NIH, 1996-1999.
Intramural
Funding
Neurobehavioral Effects of Subchronic Dietary Lead Exposure
in Fisher 344 Rats. 2005-2006.
Web-based Instruction and Multimedia Laboratory Experiences
in Biopsychology. Teaching and Learning with Technology Grant.
2002-2003.
Effects of Acute and Repeated GHB Exposure on Rat Brain
Dopamine Systems Using In Vivo Microdialysis. NeuroJumpstart
Award. 2001-2002.
Courses
Taught
Psy 372: Physiological
Psychology
Psy 378: Physiological
Psychology Laboratory
Psy 526: Human Drug Use
and Abuse
Psy 595: History of
Psychology
Psy 612: Advanced
Physiological Psychology
Psy 613: Behavioral
Pharmacology
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