Lisa Baker, Ph.D., Vanderbilt University (1989)

Back to Baker's Homepage

Educational Background

Research Interests




Courses Taught






B.A. in Psychology, State University of New York at Oswego, 1984
Ph.D. in Psychology, Vanderbilt University, 1989
Postdoctoral Training, University of South Carolina 1989-1991

Research Interests

• Behavioral Neuropharmacology
• Discriminative stimulus properties of addictive and psychotropic drugs
• Neuropharmacological actions of addictive drugs
• Substance abuse

Published Research Articles

Baker, L.E., Panos, J.J., Killinger, B.A., Peet, M.M. Bell, L.M., Haliw, L.A., Walker, S.L. (2009) Comparison of the Discriminative Stimulus Effects of Salvinorin A and its Derivatives to U69,593 and U50,488 in Rats. Psychopharmacology. 203 (2): 203-211.

Poling, A. Morgan, K., Panos, J.,  Kim, E., O'Hare, E., Cleary, J.P., Lesné, S., Ashe, K.H. Porritt, M. and Baker, L.E. (2008) Oligomers of the amyloid-beta protein disrupt working memory: confirmation with two behavioral procedures. Behavioural Brain Research.

Baker, L.E.,  Searcy, G.D., Pynnonen, D.M. and Poling, A.D. (2008) Differentiating the discriminative stimulus effects of gamma-hydroxybutyrate and ethanol in a three-choice drug discrimination procedure in rats. Pharmacology, Biochemistry and Behavior. 89(4): 598-607.

Kueh, D., Iwamoto, K., Poling, A. and Baker, L.E. (2008) Effects of γ-hydroxybutyrate (GHB) and its metabolic precursors on delayed-matching-to-position performance in rats. Pharmacology, Biochemistry and Behavior. 89(2): 179-187.

Laraway, S., Snycerski, S. Baker, L.E. & Poling A.D. (2008) Gamma-hydroxybutyrate (GHB) reduces accuracy and response rates in rats responding under fixed-consecutive-number schedules. Pharmacology, Biochemistry and Behavior. 88 (3): 205-212.

Kueh, D and Baker, L.E. (2007) Reinforcement schedule effects in rats trained to discriminate 3,4-methylenedioxymethamphetamine (MDMA) or cocaine. Psychopharmacology.189: 447-457.

Baker. L.E., VanTilburg, T.J., Brandt, A.E. and Poling, A.D. (2005) Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor, gamma-butyrolactone (GBL) in rats. Psychopharmacology. 181: 458-466.

Baker, L.E., Pynnonen, D.M. and Poling, A.D. (2004) Influence of reinforcer type and route of administration on gamma-hydroxybutyrate discrimination in rats.  Psychopharmacology. 174: 220-227.


Prus, A.J., Baker, L.E. and Meltzer, H.Y. (2004) Discriminative stimulus properties of 1.25 mg/kg and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin and cholinergic receptor mechanisms. Pharmacology, Biochemistry and Behavior. 77: 199-208.


Goodwin, A.K., Pynnonen, D.M. and Baker, L.E. (2003) Serotonergic-dopaminergic mediation of MDMA’s discriminative stimulus effects in a three-choice discrimination. Pharmacology, Biochemistry and Behavior. 74, 987-995.


Goodwin, A. K., & Baker, L. E.  (2002).  An analysis  of the utility of differential outcome procedures in drug discrimination research.  Behavioural Pharmacology, 13, 271-278.


Baker, L. E., & Prus, A. J.  (2002).  Reevaluation of PNU-99194A discriminative stimulus effects:  Potentiation by both a D2 antagonist and a D3/D2 agonist.  Pharmacology, Biochemistry and Behavior, 73, 753-758.


Goudie, A. J., Baker, L. E., Smith, J. A., Prus, A. J., Svensson K. A., Cortes-Burgos L. A., Wong E. H. F., & Haadsma-Svensson, S.  (2001).  Common discriminative stimulus properties in rats of muscarinic antagonists, clozapine and the D3 preferring antagonist PNU-99194A: an analysis of possible mechanisms.  Behavioural Pharmacology, 12, 303-15.


Christian, A. C., Goodwin, A. K., & Baker, L. E.  (2001).  Antagonism of the discriminative stimulus effects of (+)-7-OH-DPAT by remoxipride but not by PNU-99194A. Pharmacology Biochemistry and Behavior, 68, 371-377.

Byrne, T., Baker, L. E., & Poling, A. D.  (2000).  MDMA and learning: effects of acute and neurotoxic exposure in the rat.  Pharmacology Biochemistry and Behavior, 66, 501-508.

Goodwin, A. K., & Baker, L. E.  (2000).  A three-choice drug discrimination procedure dissociates the discriminative stimulus effects of MDMA and d-amphetamine. Experimental and Clinical Psychopharmacology, 8, 415-423.

Baker, L. E., Hood, C. A., & Heidema, A. M.  (1999).  Assessment of D3 versus D2 receptor modulation of the discriminative stimulus effects of (+)-7-OH-DPAT in rats.  Behavioural Pharmacology, 10, 717-722.

Garner K. J., & Baker, L. E. (1999).  Analysis of D2 and D3 receptor selective ligands in rats trained to discriminate cocaine from saline.  Pharmacology Biochemistry and Behavior, 64, 373-378.

Virden, T. B., & Baker, L. E.  (1999).  Disruption of the discriminative stimulus effects of S(+)-3, 4-methylenedioxymethamphetamine (MDMA) by (±)-MDMA neurotoxicity: protection by fluoxetine.  Behavioural Pharmacology, 10, 195-204..

Baker, L. E., Garner, K. J., Goodwin, A. K., & Svensson, K. A.  (1998).  The dopamine D3 receptor antagonist PNU-99194A fails to block (+)-7-OH-DPAT substitution for d-amphetamine or cocaine.  European Journal of Pharmacology, 358, 101-109.

Franklin, S. R., Baker, L. E., & Svensson K. A.  (1998).  Discriminative stimulus properties of the dopamine D3 antagonist PNU-99194A.  Psychopharmacology, 138, 40-46.

Baker, L. E., Virden, T. B., Miller, M. E., & Sullivan, C. L.  (1997).  Time course analysis of the discriminative stimulus effects of the optical isomers of 3,4-methylenedioxymethamphetamine (MDMA).  Pharmacology Biochemistry and Behavior, 58, 505-516.

Baker, L. E., Miller, M. E., & Svensson, K.  (1997).  Assessment of the discriminative stimulus effects of the selective dopamine D3 antagonist PNU-99194A in rats: Comparison to psychostimulants.  Behavioral Pharmacology, 8, 243-252.

Morgan, T. B., & Baker, L. E.  (1997).  The application of differential outcomes to a cocaine - saline discrimination procedure. Behavioural Pharmacology, 8, 1-6.

Baker, L. E., & Taylor M. M.  (1997).  Assessment of the MDA and MDMA optical isomers in a stimulant-hallucinogen discrimination.  Pharmacology Biochemistry and Behavior, 57, 737-748.

Baker, L. E., & Makhay, M. M.  (1996).  Effects of (+)-fenfluramine on 3,4-methylenedioxy-methamphetamine (MDMA) discrimination in rats.  Pharmacology, Biochemistry and Behavior, 53, 455-461.


Baker, L.E., Broadbent, J.B. Michael, E.K., Matthews, P.K., Metosh, C.A., Saunders, R.B., West, W.B. and Appel, J.B. (1995) Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4‑methylenedioxymethamphetamine; MDMA).  Behavioral Pharmacology.  6:  263-275.


Baker, L.E., Riddle, E.E., Saunders, R.B., and Appel, J.B. (1993) The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds.  Behavioral Pharmacology. 4: 69-79


Appel, J. B., Baker, L.  E., Barrett, R. L., Broadbent J., Michael, E. K., Riddle, E. E. and Van Groll, B.J. (1991) The use of drug discrimination in drug abuse research. NIDA Research Monograph Series. 116: 369-397.


Federally Funded Grants


GHB: Discrimination and Effects on Learning. R01 grant funded by the NIH, 2001–2004.


A Three-Lever Discrimination of MDMA and LSD in Rats. NRSA funded by the NIH for doctoral student Amy Goodwin, 2000–2002.


Dopamine D3 Receptors in Psychostimulant Discrimination. R03 grant funded by the NIH, 1996-1999.


Intramural Funding

Neurobehavioral Effects of Subchronic Dietary Lead Exposure in Fisher 344 Rats. 2005-2006.

Web-based Instruction and Multimedia Laboratory Experiences in Biopsychology. Teaching and Learning with Technology Grant. 2002-2003. 

Effects of Acute and Repeated GHB Exposure on Rat Brain Dopamine Systems Using In Vivo Microdialysis.  NeuroJumpstart Award.  2001-2002.

Courses Taught
Psy 372: Physiological Psychology
Psy 378: Physiological Psychology Laboratory
Psy 526: Human Drug Use and Abuse
Psy 595: History of Psychology
Psy 612: Advanced Physiological Psychology
Psy 613: Behavioral Pharmacology

Department of Psychology
3700 Wood Hall
Western Michigan University
Kalamazoo, MI 49008
(269) 387-4500