Selected Publications

Huffman, D. L.; Suslick, K. S. "Hydrophobic Interactions in Metalloporphyrin-Peptide Complexes", Inorg. Chem. 2000, 39, 5418-19.

Huffman, D. L.; O'Halloran, T. V. "Energetics of Copper Trafficking Between the Atx1 Metallochaperone and the Intracellular Copper-Transporter, Ccc2",
J. Biol. Chem. 2000, 275, 18611-18614.

Wernimont, A. K.; Huffman, D. L.; Lamb, A. L.; O'Halloran, T. V.; Rosenzweig, A. C. "Structural Basis for Copper Transfer by the Chaperone for the Menkes/Wilson Disease Protein",
Nature Struct. Biol. 2000, 7, 766-771.

Banci, L.; Bertini, I.; Ciofi-Baffoni, S.; Huffman, D. L.; O'Halloran, T. V. "Solution structure of the yeast copper transporter domain Ccc2a in the apo and Cu(I) loaded states",
J. Biol. Chem. 2001, 276, 8415-8426.

Huffman, D. L.; O'Halloran, T. V. "Function, Structure and Mechanism of Intracellular Copper Trafficking Proteins",
Ann. Rev. Biochem. 2001, 70, 677-701.

Arnesano, F.; Banci, L.; Bertini, I.; Cantini, F.; Ciofi-Baffoni, S.; Huffman, D. L.; O'Halloran, T. V. "Characterization of the binding interface between the copper chaperone Atx1 and the first cytosolic domain of Ccc2 ATPase", J. Biol. Chem. 2001, 276, 41365-41376. http://www.jbc.org/cgi/content/full/276/44/41365

Outten, F. W.; Huffman, D. L.; Hale, J; O'Halloran, T. V. "The Independent cue and cus Systems Confer Copper Tolerance During Aerobic and Anaerobic Growth in Escherichia coli", J. Biol. Chem. 2001, 276, 30670-30677.
http://www.jbc.org/cgi/content/full/276/33/30670

Arnesano, F.; Banci, L.; Bertini, I.; Ciofi-Baffoni, S.; Molteni, E.; Huffman, D. L.; O'Halloran, T. V. "Metallochaperones and metal transporting ATPases: a comparative analysis of sequences and structures", Genome Research 2002, 12, 255-271. http://www.genome.org/cgi/content/abstract/12/2/255

Huffman, D. L.; Huyett, J.; Outten, F. W.; Finney, L. A.; Doan, P. E.; Hoffman, B. M.; O'Halloran, T. V. "ENDOR spectroscopy of Cu(II)-PcoC and the multicopper oxidase function of PcoA, two essential components of the pco copper resistance operon in Escherichia coli", Biochemistry 2002, 41, 10046-55.

Rosenblatt, M. M.; Huffman, D. L.; Wang, X.; Remmer, H. A.; Suslick, K. S. "Cyclic and Hairpin Peptide Complexes of Heme", J. Am. Chem. Soc. 2002, 124, 12394-5. (Communication)

Peariso, K.; Huffman, D. L.; Penner-Hahn, J. E.; O'Halloran, T. V. "The Escherichia coli Copper Resistance Protein PcoC Coordinates Cu(I) via Novel S-Methionine Interactions", J. Am. Chem. Soc. 2003, 125, 342-3. (Communication)

Wernimont, A. K.; Huffman, D. L.; Finney, L. A.; Demeler, B.; O'Halloran, T. V.; Rosenzweig, A. C. "Crystal Structure and Dimerization Equilibria of PcoC, a Methionine Rich Copper Resistance Protein from Escherichia coli", J. Biol. Inorg. Chem. 2003, 8, 185-94.

Achila, D.; Banci, L.; Bertini, I.; Bunce, J.; Ciofi-Baffoni, S.; Huffman, D. L. "Structure of human Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake", Proc. Natl. Acad. Sci. USA 2006, 103, 5729-34.

Bunce, J.; Achila, D.; Hetrick, E.; Lesley, L.; Huffman, D. L. "Copper Transfer studies between the N-terminal copper binding domains one and four of human Wilson protein", Biochim. Biophys. Acta. 2006,1760, 907-12.

Benitez, J. J.; Keller, A. M.; Ochieng, P.; Yatsunyk, L. A.; Huffman, D. L.; Rosenzweig, A. C.; Chen, P. "Probing transient coppper chaperone Wilson disease protein interactions at the single-molecule level with nanovesicle trapping", J. Am. Chem. Soc. 2008, 130, 2446-7.