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Fall Semester, 0000

Department of Biological Sciences

Western Michigan University



"If you can see only what light reveals

and hear only what sound announces,

Then in truth you do not see nor do you hear"


[Kahlil Gibran in 'Sand and Foam' 1926]






Instructor: Dr. K. Essani, Professor.


Office Hours: Mondays 1:00-3:00 and Tuesdays 2:30-4.00 pm


2007 Haenicke Hall

Telephone: 387-2661; Internet:


Prerequisites: BIOS 3120, Biochemistry recommended.


This course is intended to introduce undergraduate and graduate students to recent concepts in the biology and biochemistry of mammalian immune system. A general knowledge of microbiology and biochemistry (of nucleic acids and proteins) at least at the present high school level, will be essential to understand lectures and readings. Emphasis will be placed to enhance analytical abilities of students. Immunology has become an integral part of all modern biomedical sciences, and is the fastest growing discipline. It is expected that by the end of this semester, the students should be able to comprehend and critically review important immunology articles in leading scientific journals. Some analytical questions from the recent development in immunology will be included in the Final Exam. These journals are available in the university library. Some informative and useful web sites covering wide range of topics in immunology are also available on the internet. Surfing this information is highly recommended.


Time and Place: Tuesdays and Thursdays, 6:00 7:50 p.m.

2908 Wood Hall


Credit Hours: 4.0


Text: Immunology , 3rd. Edition.

Janis Kuby, W. H. Freeman and Company, 1997


The purpose of the textbook is to provide students with some conceptual background to comprehend the material presented in lectures and suggested in reading assignments. However, this book contains a number of omissions and factual errors. Emphasis should therefore be placed on lectures and readings.


Exams and Scoring: A total of 100 points with four scoring opportunities as follows:


First Exam. --------------------------- 20 points

Second Exam ------------------------ 20 points

Third Exam -------------------------- 20 points

Final Exam --------------------------- 40 points

The FINAL [COMPREHENSIVE] EXAM will be constructed as follows: 15 points from lectures covered in three previous exams [some questions may be from previous exams], and 25 points from lectures since third exam. Some basic biochemistry questions may be included in all exams.

Total numerical grade obtained by summing all scoring opportunities will translate into letter grade as follows:

90-100 = A, 85-89 = BA, 79-84 = B, 72-78 = CB.

65-71 = C, 57-64 = DC, 50-56 = D, 0-49 = E.


Computer Usage:


Although initial guidance will be provided, students are required to self-teach the use of computer systems and data banks. Terminals are available in computer labs located in Bernhard (387-2410) and Academic Computer Centers (387-2411). Technical assistance is available at both centers.


Make-up Exams:


Any make-up exam will be by special arrangements only, and will require written documentation for an excused absence. Exams are to be made up immediately after return to class and only approved excused absences are eligible for a make-up exams.



Academic Honesty:


Academic ethical standards regarding cheating, fabrication, plagiarism, facilitating academic dishonesty and consequences of these actions are all described in the WMU Undergraduate Catalog. Students sometimes do not understand the definitions of academic standards (e.g. plagiarism) and unwittingly are party to improper conduct. Thus it is important to familiarize yourself with this part of the written definitions described above. Reading these regulations is strongly recommended.



Meeting # Topic


[Note: Some lectures may cover two meetings]


1. An overview of immunology and innate immunity.


2. Recombinant DNA technology in immunology and molecular biology resources on line.


3. Interferons and complement system.


4. Eosinophils [Guest Lecturer: Robert Eversole]


5. Adaptive immunity and cells involved in the immune response.


6. First Exam. [30 minutes].

Immunogenecity and immunohematology.


7. Immunoglobulins I. Structure and function.


8. Immunoglobulins II. Gene organization.


9. Monoclonal Antibodies


10. Major histocompatibility complex.


11.                                                      Cell-mediated immune responses.


12. Review and Discussion.


13. Second Exam.


14. T-cell receptors.


15. Regulation of the immune response.


16.. Hypersensitivity I. Immediate.


17. Hypersensitivity II. Delayed [cell-mediated].


18. Immune tolerance.


19. Transplantation immunology.


20. Review and Discussion.


21. Third Exam.


22. Autoimmunity.


23. Immunological Techniques.


24. Vaccines.


25. Immunology of AIDS.


26.                                                     Review and Discussion.


27. Final [Comprehensive] Exam.