EKKEHARD SINN
Professor
WMU Department of Chemistry,   Kalamazoo, MI 49008-5413
Phone 269-387-2832       FAX 269-387-2909

BA 1972 (Anthropol&Chinese) U of Sydney
BSc (Physics&Math), MSc (Phys Chem) Sydney
PhD (Inorg Chem) U of New South Wales
        F.R.A.C.I.       CChem       FRSC
  ekk.sinn@wmich.edu       
                 
•Recent Publications
•More Publications - The Early Days

RESEARCH

Everything in the Chemist's world revolves around the outermost electrons of atoms.
How we pair them or not governs how biomolecules work, what magnetism we get,
and what new kinds of smart materials we can make. Follow a humble inorganic
chemist's path as it touches some of the fascinating possibilities of our world:

ENZYMES

CANCER KILLERS; AND A WARNING SHOT AT OTHER DISEASES

NEW INFORMATION STORAGE DEVICES

NEW KINDS OF LASERS

MOLECULAR MAGNETS

DESIGNER CATALYSTS

MOLECULAR ELECTRONICS

METAL CONTAINING LIQUID CRYSTALS

OTHER NEW MATERIALS

SENSING TOXIC MATERIALS

IRON SEQUESTERERS (SIDEROPHORES) and GRABBERS OF OTHER METAL ATOMS

Measuring bond lengths directly in mixed spin systems without crystallography or NMR

AGING PROCESS (before it's too late)

and MORE

Also we'll look at ways we can get it wrong

WHO SAID CHEMISTRY ISN'T INTERESTING!


Group_Meeting

Group Meeting... Sebastian Brainerd, Carla Sue Eribal, Rasanji Madawala, Sajini Devadas,
Fasil Abebe, Mark Allen, Ekk, Aruna Weerasinghe
Absent: Amr Ezatt, Viraj D. Thanthirige, Tom R. Burghard, Bharathi Balagam




Hoffmann visit






RESEARCH

SELECTED RECENT PUBLICATIONS

331. N-Heterocyclic carbenes in organofluorine chemistry. V. Prakash Reddy, Avinash Vadapalli, Ekkehard Sinn and Narayan Hosmane, J. Organomet. Chem. 2013, 000, 000-000 .

330. Synthesis, X-ray crystal structures, spectroscopic and electrochemical studies of Zn(II), Cd(II), Ni(II) and Mn(II) complexes of N1,N4-bis(pyridoxylidene)triethylenetetramine - a Zn2+ turn-on Fluorescent Sensor in aqueous solution. Satyajit Mondal, Piyali Adak, Sumita Naskar, Chandrima Das, Arnold L. Rheingold, Ekkehard Sinn, Carla Eribal and Shyamal Kumar Chattopadhyay, Polyhedron 2013, 000, 000-000 .

329. Mixed-ligand nickel(II) thiosemicarbazone complexes: Synthesis, characterization and biological evaluation. Rupam Dinda, Carla S. Schmiesing, Ekkehard Sinn, Yogesh P. Patil, M. Nethaji, Helen Stoeckli-Evans and Rama Acharyya, Polyhedron 2013, 50, 354-363, dx.doi.org/10.1016/j.poly.2012.11.031.

328. Mononuclear and binuclear Cu(II) complexes of some tridentate aroyl hydrazones. X-ray crystal structures of a mononuclear and a binuclear complex. Satyajit Mondal, Sumita Naskar, Ayan Kumar Dey, Ekkehard Sinn, Carla Eribal, Steven R. Herron and Shyamal Kumar Chattopadhyay, Inorg. Chim. Acta 2013, 398, 98-105, DOI:10.1016/j.snb.2012.10.069.

327. Novel fully screen printed flexible electrochemical sensor for the investigation of electron transfer between thiol functionalized viologen and gold clusters. Binu Baby Narakathu, Mary Sajini Devadas, Avuthu Sai Guruva Reddy, Ali Eshkeiti, Akhil Moorthi, Isurika R. Fernando, Bazsa P. Miller, Guda Ramakrishna, Ekkehard Sinn, Margaret Joyce, Marian Rebros, Erika Rebrosova, Gellert Mezei and Massood Zandi Atashbar, Sensors and Actuators, B: Chemical 2013, 176, 768-774, DOI:10.1016/j.snb.2012.10.069.

326. Accessibility and Selective Stabilization of the Principal Spin States of Iron by Pyridyl versus Phenolic Ketimines: Modulation of the 6A1 <--> 2T2 Ground-State Transformation of the [FeN 4O2]+ Chromophore. Musa S. Shongwe, Usama A. Al-Zaabi, Faizah Al-Mjeni, Carla Sue Eribal, Ekkehard Sinn, Immaddin A. Al-Omari, Hussein H. Hamdeh, Dariusz Matoga, Harry Adams, Micheal J. Morris, Arnold L. Rheingold, Eckhard Bill and David J. Sellmyer, Inorg. Chem. 2012, 51(15), 8241-8253, DOI:10.1021/ic300732r

325. Synthesis and Characterization of Pyruvate-isoniazid Analogs and their Copper Complexes as Potential ICL Inhibitors. Dipti Shingnapurkar, Prasad Dandawate, Christopher E. Anson, Annie K. Powell, Zahra Afrasiabi, Ekkehard Sinn, Shital Pandit, Swamy K. Venkateswara, Scott Franzblau and Subhash Padhye, Bioorg. Med. Chem. Lett. 2012, 22(7), 3172-3176, DOI:10.1016/j.bmcl.2012.03.047.

324. Temperature-Dependent Optical Absorption Properties of Monolayer-Protected Au25 and Au38 Clusters. Mary Sajini Devadas, Semere Bairu, Huifeng Qian, Ekkehard Sinn, Rongchao Jin, and Guda Ramakrishna, The Journal of Physical Chemistry Letters, 2011, 2(21), 2752-2758, DOI:10.1021/jz2012897.

323. Rhodamine based turn-ON dual sensor for Fe3+ and Cu2+. Aruna J. Weerasinghe, Fasil A. Abebe and Ekkehard Sinn, Tetrahedron Lett. 2011, 52(43), 5648-5651, doi:10.1016/j.tetlet.2011.08.092.

319. Epitaxial electrodeposition of chiral CuO films from copper(II) complexes of malic acid on Cu(111) and Cu(110) single crystals. Rakesh V. Gudavarthy, Niharika Burla, Elizabeth A. Kulp, Steven J. Limmer, Ekkehard Sinn and Jay A. Switzer J. Mater. Chem., 2011, 21(17), 6209-6216, 00. DOI: 10.1039/C0JM03423A

318. Synthesis, Characterization, and Evaluation of Rhodamine Based Sensors for Nerve Gas Mimics. Aruna J. Weerasinghe, Carla Schmiesing and Ekkehard Sinn, Tetrahedron, 2011, 67, 2833-2838.

317. Unique Ultrafast Visible Luminescence in Monolayer-Protected Au25 Clusters. Mary Sajini Devadas, Junhyung Kim, Ekkehard Sinn, Dongil Lee, Theodore Goodson III, Ramakrishna Guda, Carla Schmiesing, Shankar Varaganti and Ekkehard Sinn, J. Chem Phys. C , 2010, 114, 22417-22423.

316. Single– and Multi–Photon Turn-On Fluorescent Fe3+ Sensors based on Bis (rhodamine). Aruna J. Weerasinghe, Ramakrishna Guda, Carla Schmiesing, Shankar Varaganti, Ekkehard Sinn, J. Chem Phys. B , 2010, 114, 9413-9419. DOI: 10.1021/jp1034568

315. Directional Electron Transfer in Chromophore Labeled Quantum Sized Au25 Clusters: Au25 as Electron Donor. Mary Sajini Devadas, Kyuju Kwak, Jung-Woo Park, Ji-Hwan Choi, Chul-Ho Jun, Ekkehard Sinn, Guda Ramakrishna, Dongil Lee, J. Chem Phys. Lett. , 2010, 1, 1497-1503. http://DOI: 10.1021/jz100395p DOI: 10.1021/jz100395p

315. Directional Electron Transfer in Chromophore Labeled Quantum Sized Au25 Clusters: Au25 as Electron Donor. Mary Sajini Devadas, Kyuju Kwak, Jung-Woo Park, Ji-Hwan Choi, Chul-Ho Jun, Ekkehard Sinn, Guda Ramakrishna, Dongil Lee, J. Chem Phys. Lett. , 2010, 1, 1497-1503. http://DOI: 10.1021/jz100395p

314. Highly Sensitive and Selective Reversible Sensor for the Detection of Cr3+,. Aruna J. Weerasinghe, Carla Schmiesing and Ekkehard Sinn, Tetrahedron Lett. , 2009, 50, 6407-6410. http://dx.doi.org/10.1016/j.tetlet.2009.08.025

313. A Novel Copper(II) Complex of a Tripodal Ligand with Phenolate-Phenol Interligand Intramolecular Hydrogen Bonding. Vaidyanathan Mathrubotham, Anthony W. Addison, K. Travis Holman, Ekkehard Sinn and Laurence K. Thompson, J. Chem. Soc., Dalton Trans., 2009, DOI: 10.1039/b910188h

312. Synthesis, Characterization, and Reactivity of Iron Trisamidoamine Complexes that undergo both Metal- and Ligand-Centered Oxidative Transformations. Remle Celenligi-Cetin, Patrina Paraskevopolou, Rupam Dinda, Richard J. Staples, Ekkehard Sinn, Nigam P. Rath and Pericles Stavropoulos, Inorg. Chem. Comm., 2008, 47, 1165-1172.

311. Oxidative Ligand Rearrangement due to Incipient Aminyl Radicals in the Oxidation of Iron(II) Species with Dioxygen. Remle Celenligi-Cetin, Patrina Paraskevopolou, Rupam Dinda, Nikolia Lalioti, Yiannis Sanakis, Abdel Monem Rawashdeh, Richard J. Staples, Ekkehard Sinn and Pericles Stavropoulos, European Journal of Inorg. Chem., 2008, 5, 673-677.

310. Copper complexes of henna-sulforaphane conjugates as potent antiproliferative agents against human myeloma KBM-5 cells through blockade of transcription factor NF-KB. K. Shirisha, J. Patole, S. Padhye, E. Sinn, S. Shishodia and B. B. Aggarwal, Letters in Drug Design & Discovery, 2007, 4, 257-262.

309. Copper Conjugates of Nimesulide Schiff Bases Targeting VEGF, COX, and BcI-2 in Pancreatic Cancer Cells. Vinita Ambike, Shreelekha Adsule, Fakhara Ahmed, Zhiwei Wang, Zahra Afrasiabi, Ekkehard Sinn, Fazlul Sarkar and Subhash Padhye, Inorg. Biochem., 2007, 99, 1517-1524.

308. Neutral dimeric copper-sparfloxacin conjugate having butterfly motif with antiproliferative effects agains hormone dependent BT20 breast cancer cell line. Dipti Shingnapurkar, Ray Butcher, Zahra Afrasiabi, Ekkehard Sinn, Fakhara Ahmed, Fazlul Sarkar and Subhash Padhye, Inorg. Chem. Comm., 2007, 10, 459-462.

307. Nickel(II) Complexes of Naphthaquinone Thiosemicarbazone and Semicarbazone: Synthesis, Structure, Spectroscopy and Biological Activity. Zahra Afrasiabi, Ekkehard Sinn, Weisheng Lin, Yinfa Ma, Charles Campana and Subhash Padhye, Inorg. Biochem., 2005, 99, 1526-1531.

306. Antitumor Metallothiosemicarbazonates: Structure and Antitumor Activity of Palladium Complex of Phenanthrenequinone Thiosemicarbazone. Subhash Padhye, Zahra Afrasiabi, Ekkehard Sinn, J Fok, K Mehta, Nigam Rath, D. Deobagakar, Chris E Anson and Annie K Powell, Inorg. Chem., 2005, 44, 1154.

305. Gadolinium Triflate Immobilized in Imidazolium Based Ionic Liquids: a Recyclable Catalyst and Green Solvent for Acetylation of Alcohols and Amines. Ramesh Alleti, Woon Su Oh, Meher Perambuduru, Zahra Afrasiabi, Ekkehard Sinn and V. Prakash Reddy. Green. Chem., 2005, 7, 203.

303. The Cytotoxicity and Mechanisms of 1,2 Naphthoquinone Thiosemicarbazone and Its Metal Derivatives Against MCF-7 Human Breast Cancer Cells. Junan Chen, Y. Huang, Guotao Liu, Zahra Afrasiabi, Ekkehard Sinn, Subhash Padhye and Yinfa Ma, Toxicol. and Appl Pharmacol., 2004, 197, 40.

301. Appended 1,2-naphthoquinones as anticancer agents 1: synthesis, structural, spectral and antitumor activities of ortho-naphthaquinone thiosemicarbazone and its transition metal complexes. Zahra Afrasiabi, Ekkehard Sinn, Junan Chen, Yinfa Ma, Arnold L. Rheingold, Lev N. Zakharov, Nigam Rath and Subhash Padhye. Inorg, Chim. Acta., 2003, 357, 271.

300. Synthesis and Mesogenic Properties of Binuclear Copper (II) Complexes Derived from Salicylaldimine Schiff Bases. Reinhard Paschke, Stefan Liebsch, Carsten Tschierske, Michael A. Oakley and Ekkehard Sinn, Inorg. Chem., 2003, 42, 8230.

299. Structural Study of the Thermal and Photo-chemical Spin States in the Spin Crossover Complex [Fe(phen)2(NCSe)2 ]. Catherine M. McGrath, C. Sangregorio, Jonathan W. M. Seddon, Ekkehard Sinn, Frank E. Sowery, Simon J. Teat, G.B.M. Vaughan and Nigel A. Young, Chemistry: A European Journal, 2003, 9, 5314.

298. Hemiprotonated dafone, a new cationic species. The novel di-dafonium iron(III) complex: [(dafone)2H]+[FeCl4-]. Kulkarni, P.; Padhye, S.; Sinn, E. Inorg. Chem. Comm., 2003, 6, 1129.

297. Transition metal complexes of Phenanthenequinone Thiosemicarbazone as Potential Anticancer Agents: Synthesis, Structure, Spectroscopy, Electrochemistry and in vivo Anticancer Activity Against Human Breast Cancer Cell-line T47D. Zahra Afrasiabi, Ekkehard Sinn. Shreelakha Padhye, Sabari Dutta, Subhash Padhye, Chris Newton, Christopher E. Anson and Annie K. Powell, J. Inorg. Biochem., 2003, 95, 306.

296. Cholic Acid - Carboplatin Compounds (ChAPt) as Models for Specific Drug Delivery. Synthesis of novel carboplatin analogous derivatives and comparison of the cytotoxic properties with corresponding cisplatin compounds. Paschke, R.; Kalbitz, J.; Paetz, C.; Luckner, M.; Mueller, T.; Mueller, H.; Sorkau, E.; Sinn E., J. Inorg. Biochem., 2003, 94, 335.

295. Biomolecules Linked to transition metal complexes New Chances for Chemotherapy. Reinhard Paschke, Christian Paetz, Thomas Mueller, Hans-Joachim Schmoll, Helmut Mueller, Eduard Sorkau and Ekkehard Sinn, Current Medicinal Chemistry, 2003, 10, 1241.

294. Cis Di-oxomolybdenum(VI) Complexes with a Tridentate ONO Donor Ligand; Synthesis, X-ray Crystal Structure, Spectroscopic Properties and Oxotransfer Chemistry. Uday Sandbhor, Subhash Padhye and Ekkehard Sinn, Transition Met. Chem., 2002, 27, 681.

293. New Principles in Metallomesogen Structure-Magnetism Correlations. Stefan Liebsch, Michael A. Oakley, Reinhard Paschke and Ekkehard Sinn, Inorg. Chem. Comm., 2002, 5, 525.

292. Lowering Melting Points in Asymmetrically Substituted Salen-Copper(II) Complexes Exhibiting Mesomorphic Behavior. Structure of the Mesogen Cu(5-hexyloxySalen). Reinhard Paschke, DĀrte Balkow, and Ekkehard Sinn Inorg. Chem., 2002, 41, 1949.

291. Comparative studies on Copper(I) complexes: Synthesis, x-ray crystallography and electrochemical properties of [CuI(dafone)nX] complexes (dafone = 4,5-diaza-fluoren-9-one, X = Br, I, SCN). Prasad Kulkarni, Subhash Padhye, Ekkehard Sinn, Christopher E. Anson and Annie K Powell, Inorg. Chim. Acta, 2002, 332, 167.

290. The First Uranium Based Liquid Crystals. Uranyl Metallomesogens from ß-diketonate and Tropolone Ligands. Stephen Clark, James M Elliott, John R Chipperfield, Peter Styring, Ekkehard Sinn, Inorg. Chem. Comm, 2002, 5, 249.

289. Synthesis, structure, spectroscopy and antitumor activity of hydroxy naphthoquinone thiosemicarbazone and its metal complexes against MCF-7 human breast cancer cell line. D K Saha, S Padhye, E Sinn, C Newton, Indian J. Chem. Sect A-Inorg. Bio-Inorg. Phys. Theor. Anal., 2002, 41, 279.

288. Liquid Crystal Phase Crossover (Columnar — Calamitic) in Polycatenar CuII 5-(3,4-dialkoxybenzylidine)aminotropolonates. James M Elliott, John R Chipperfield, Stephen Clark and Ekkehard Sinn, Inorg. Chem. Comm, 2002, 5, 99.

287. Criteria for Liquid Crystal Formation in 5-Alkoxy-, 5-Alkylamino-, and 5-Alkanoyl-tropolone Complexes of Transition Metals (CuII, ZnII, NiII, CoII, UO2VI, VOIV). The first Uranium Metallomesogen. Crystal Structure of Bis(5-hexadecyloxytropolonato)copper(II). James M. Elliott, John R. Chipperfield, Stephen Clark, Simon J Teat and Ekkehard Sinn Inorg. Chem., 2002, 41, 293. text .

286. Cross-over Phase Behavior (Discotic to Calamitic) in Liquid-crystalline Copper Complexes. Dependence on Length and Position of Alkoxy Chains in new Polycatenar Bis[5-(dialkoxybenzylidine)aminotropolonato]copper(II) Complexes. James M Elliott, John R Chipperfield, Stephen Clark and Ekkehard Sinn, Inorg. Chem., 2001, 40, 6390. graphic . text .

285. Neutral metal complex in an ionic pocket: synthesis, physicochemical properties and X-ray structure of a copper(II) complex containing neutral as well as cationic dafone ligands and dafonium perchlorate. Prasad Kulkarni, Subhash Padhye and Ekkehard Sinn, Inorg. Chim. Acta, 2001, 319, 193.

284. Tuning up Superoxide Dismutase Activity of Copper Complex of Salicylaldehyde Semicarbazone by Heterocyclic Bases Pyridine and N-methylimidazole. J Patole, S Dutta, S Padhye, and E Sinn, Inorg. Chim. Acta, 2001, 318, 2435.

283. Copper-Catalysed Asymmetric 1,4-Addition of Organozinc Compounds to Linear Aliphatic Enones Using 2,2'-Dihydroxy-3,3'-Dithioether Derivatives of 1,1'-Binaphthalene. Christoph Börner, Michael R Dennis, Ekkehard Sinn, Simon Woodward, Eur. J. Org. Chem., 2001, 2435.

282. Modeling of the Ni-Fe-center of Ni-CO-dehydrogenase by Nickel Complexes with Thiazaligands. V.V. Pavlishchuk, S.V. Kolotilov, A.W. Addison, M.J. Prushan, R.J. Butcher, E. Sinn, Ukr. Biokhim. Zh., 2001, 73, 91.

278. Nickel(II) complexes with Dithiadiiminoamine and dithiabis(thiosemicarbazone) ligands. V V Pavlishchuk, S V Kolotilov, A W Addison, R J Butcher, E Sinn, J. Chem. Soc., Dalton Trans., 2000, 335. text .

276. Direct Measurement of the High-spin and Low-spin M-L Bond Lengths and the Spin State Population in Mixed Spin Systems: an Fe K-edge XAFS Study of Iron(III) Dithiocarbamate Complexes. C M McGrath, C J O'Connor, C Sangregorio, J M W Seddon, E Sinn, F E Sowrey, N A Young, Inorg. Chem. Comm., 1999, 2,536.

260. The Effect of Low Molecular Weight Organosiloxane Substituents on Mesophase Formation and Structure in Non-Symmetric Nickel(II) Complexes. I M Saez, G H Mehl, E Sinn, P Styring, J. Organomet. Chem., 1998, 551, 299.

255. Catalytic Conjugate Addition Promoted by the Copper(I)-Monothiobinaphthol System. Part 2. Optimal Ligand Synthesis and Initial Catalytic Results. S M Azad, S M W Bennett, S M Brown, J Green, E Sinn, C M Topping, S Woodward, J. Chem. Soc., Perkin Trans. 1, 1997, 687.

250. The First Oxovanadium(V)-thiolate Complex. [VO(SCH2 CH2 )3 N ]. K K Nanda, A W Addison, E Sinn, Inorg. Chem., 1996, 35, 1.

239. Peroxo aminopolycarboxylato vanadate(V) of an unusually low toxicity: synthesis and structure of the very stable K[VO(O2)(C6H6NO6)].2H2O. C Djordjevic, P L Wilkins, E Sinn, R J Butcher, Inorg. Chim. Acta 1995 230 241.



                                            "UNDER CONSTRUXION IN PERPETUUM"

Mar13