CURRICULUM VITAE

PERSONAL:

Name: Gyula Ficsor

Date and Place of Birth: April 11, 1936; Kiskunhalas, Hungary

Lives in the U.S. since 1957. U.S. Army Veteran

Citizenship: U.S. Citizen

Office Address: Department of Biological Sciences

3435 Wood Hall

Western Michigan University

Kalamazoo, MI 49008

(616)387-5633

FAX: (616)387-5609

Email: ficsor@wmich.edu

Home Address: 26648 CR 653

Gobles, MI 49055

(616)628-4005

ACADEMIC DEGREES:

B.S. 1960 Colorado State University

(Crop Science)

Ph.D. 1965 University of Missouri

(Genetics)

PROFESSIONAL APPOINTMENTS:

1965-1966 NIH Postdoctoral Fellow, Department of Genetics,

Trinity College, Dublin, Ireland

1967-1967 Research Associate, Laboratory of Molecular Biology,

University of Wisconsin

1967-1972 Assistant Professor of Biology, Department of Biology,

Western Michigan University, Kalamazoo, MI

1972-1979 Associate Professor of Biology, Department of Biology,

Western Michigan University, Kalamazoo, MI

1973 NAS Exchange Scientist, Hungary

1976 Visiting Scientist at NIEHS

1985 Visiting Professor,

Duke University Medical Center

1980-Present Professor of Biomedical Sciences

Biological Sciences Department

Western Michigan University, Kalamazoo, MI

1995 Visiting Professor, University of Szeged

Szeged, Hungary

RESEARCH INTERESTS:

Mutagenesis in mammals. Cooperative learning in genetics. Enhancement of genotoxicity by heavy metals.

TEACHING INTERESTS (courses currently offering at various intervals):

Biological Sciences 250 General Genetics (Undergraduate course)

Biological Sciences 497 Senior Seminar: Environemnt and Health Interactions Biological Sciences 420 Human genetics

Biological Sciences 620 Mutagenesis/Carcinogenesis (Postgraduate course)

FUNDED RESEARCH GRANTS (direct costs shown):

1967-1997 Eight Faculty Research Fellowships and Grants and numerous grants to students from Western Michigan University

1979-1987 International Research and Dev. Co.

$47,000

1981-1983 National Institutes of Health (Dr. Ginsberg Co-PI)

$61,518

1983-1984 U.S. Air Forces (Dr. Ginsberg Co-PI).

$25,000

1988-1990 National Institutes of Health Academic Enhancement Award.

$50,000

1994-1997 Center for Research in Environmental Signal Transmission (shared with 11 Departmental faculty).

Approx. $200,000

1997-1999 National Science Foundation Laboratory Instrumentation Award (Drs. Ginsberg and Essani Co-PI)

$67,832

1999-2002 National Institutes of Health. Individual-centered Bridges to Biomedical Research Careers (Dr. Ginsberg Co-PI). $600,000

SERVICE:

1970 All University Committee on Undergraduate Education, Chairperson

1983-1987 Arts and Sciences College Promotion Committee (Chair, 1987)

1981-1988 Departmental Graduate Advisor

1988-1992 Departmental Minor Advisor

1987-1990 Research Policies Council

1991-1994 Human Subject Institutional Review Board

1991-1994 College Curriculum Committee

1993-1994 Department Curriculum Committee Chair

1995-2001 Arts & Science College Pre-Professional Committee

1995-1996 Faculty Advisor to Minority Biological Sciences Association

1997-2001 Pre-Health Professions Faculty Mentor, College of Arts and Sciences

1998-2001 Arts and Sciences College Curriculum Committee

1999-2001 AAUP Association Council/Department AAUP Representative

 

HONORS AND AWARDS:

    1. 1971 The Ficsor, Muthiani paper on the use of liver homogenates for metabolizing mutagenic/carcinogenic agents was acknowledged as an input of the development of the Ames test.

1973 Selected by the National Academy of Sciences to be an Exchange Scientist to Hungary.

1976 Sabbatical Leave at the National Institute of Environmental Health Sciences.

1979 Asked to serve on a panel to evaluate the status of the host and fluid mediated assays in comparison to other methods of detecting mutagens and carcinogens. Held in Washington D.C.

1980 Invited for a brief research visit to the Swiss Federal Horticulture Institute at Wadenswil, Switzerland.

1985 Visiting Professor at Duke University Medical Center.

1988 Asked to serve on a review panel to evaluate NIH grant proposals in reproductive biology in Bethesda, MD.

1989 Michigan Association of Governing Boards Faculty Honoree of Western Michigan University.

PUBLISHED ABRACTS OF PRESENTATIONS AT PROFESSIONAL SOCIETY MEETINGS

1. Ficsor, G. and W.C. Beckman. 1968. Mutagenic inactivation of EMS in water and in germinating maize kernels. Genetics. 60: 176-177.

2. Ficsor, G. and G. Nii. 1970. Captan induced reversions of bacteria. Newsletter of the Environmental Mutagen Society. No. 3, p. 38.

3. Ficsor, G. and G. Nii. 1970. The effect of temperature on the mutagenicity of Captan. Newsletter of the Environmental Mutagen Society. No. 3.

4. Ficsor, G., F.C. Janaca, and C. VanHook. 1970. Tests for mutagenicity using nitrosoguanidine, DDT and Captan in maize. Newsletter of the Environmental Mutagen Society. No. 3.

5. Maliszewski, W.M.B. and G. Ficsor. 1974. Streptozotocin-induced univalents in male mice. Mutation Res. 26: 446.

6. Zuberi, R.I. and G. Ficsor. 1974. Glucose mediated mutagenicity in Salmonella typhimurium. Mutation Res. 26: 452-453.

7. Ficsor, G. and R.D. Beyer. 1975. Methodology for dosimetry of chemical mutagens in rete testis fluid of the ram. Mutation Res. 31: 331.

8. Ficsor, G. and G.F. Wertz. 1976. Polybrominated biphenyls non teratogenic, c-mitosis synergist in rat. Mutation Res. 38: 388.

9. Ficsor, G. Host- and fluid-mediated results with captan and benomyl. Poster presentation. 1976. Conference on Metabolic Activation, Wellcome Burroughs, Co., Research Triangle Park, N.C. Febr. 1976.

10. Maier, P., S. Huang, H.W. Michelmann, H.V. Malling, D.B. Feldman, and G. Ficsor. 1978. Host-mediated assays and bone-marrow cytogenetics in Rhesus monkeys (Macaca mulatta) with mitomycin C. Mutation Res. 53: 93.

11. Michelmann, H.W., P. Maier, H.V. Malling, D.B. Feldman, S. Huang, and G. Ficsor. 1978. Rhesus monkeys (Macaca mulatta) in three-tier mutagenicity testing with mitomycin C. Mutation Res. 53: 230-231.

12. Ginsberg, L.C., G. Ficsor, K.K. Block, A.S. Olafsson, and C.L. McIntire. 1979. Mouse sperm motility test to detect teratogens and mutagens. Env. Mutagenesis. 1: 194.

13. Johnson, S.C., G. Ficsor, and L.G. Ginsberg. 1980. Mitomycin C decreases sperm acrosin activity and motility in mice. Env. Mutagenesis. 2: 237.

14. Ficsor, G., N. Salama, and L.C. Ginsberg. 1981. Germ cell specific induction of proteolytic, motility and numerical sperm variants in mice by mitomycin C and ethylnitrosourea. Env. Mutagenesis. 3: 309-310.

15. Ficsor, G. and K. Sharma. 1981. Factors influencing sister chromatid exchanges in human lymphocytes. Paper presented at Mich. Acad. Sci. and Letters, Ann Arbor MI, March 1981.

16. Ginsberg, L.C., G.M. Oldford, K.R. Loughlin, and G. Ficsor. 1982. Biochemical and immunochemical analysis of single sperm in mice treated with mutagens. 13th Ann. Meet. Evn. Mut. Soc. Boston, MA. Env. Mutagenesis. 4: 319.

17 & 18.Ficsor, G., G. Oldford, A. Podraza and L. Ginsberg. Sperm and behavioral parameters for detecting mutagens. Two papers presented on this topic at the Mich. Acad. Sci. and Letters Meeting, Kalamazoo, MI, March 1982.

19. Ficsor, G. Detection of mutagens and developmentally active agents, Poster presentation at the Second Annual "Toxicology in Michigan Today" Conference, June 4, 1982, Michigan State Univ. E. Lansing, MI.

20. Ginsberg, L.C., G.M. Oldford, S. Shors, S. Smith, M. Burnhans, K. Ely, and G. Ficsor. 1983. Evaluation of sperm enzyme activities in F1 progeny of male mice treated with mitomycin C or ethylnitrosourea. Env. Mutagenesis. 5: 497-498.

21. Panda, B., R. Waibel, G. Oldford, K. Loughlin, C. Ogbu, K. Panda, G. Ficsor, and L.C. Ginsberg. 1983. Sperm enzyme and motility assays in mice to detect genotoxic and/or reprotoxic effects. Env. Mutagenesis. 5: 400-401.

22. Ficsor, G., B. Panda, and L. Ginsberg. 1983. Dominant viable testing protocol for detection of genotoxic agents in mice. Toxicol. Letters. 18: 6.

23. Ficsor, G., R. Waibel, and L. Ginsberg. 1983. Acrosin and hyaluronidase assay in single mammalian sperm for detection of reprotoxic agents. Toxicol. Letters. 18: 6.

24. Ficsor, G., B. Panda, R. Waibel, M. Burhans, G. Oldford, K. Ely, B. Imel A. Podraza, K. Loughlin and L. Ginsberg. Detection of fertility and Genetic effects of chemical substances in male mice. 4th Mich Soc. Tox. Meeting, Ann Arbor, MI. March 13, 1983.

25. Ficsor, G., B. Panda, J. Pregenzer, R. Waibel, G. Olford, and L. Ginsberg. Human sperm enzymes for detection of reprotoxic agents. Int. Sem. on Methods of Monitoring Human Exposure to Carcinogenic and Mutagenic Agents. Espoo, Finland, December 12-15, 1983.

26. Ginsberg, L.C., G. Ficsor, W.C. Keller, B.M. Llewellyn. Use of sperm enzymes to detect genotoxic Agents. AFAMRL-TR-84--020 Technical Report, 1984.

27. Ficsor, G., L.C. Ginsberg, S.P. Smith, J.F. Pregenzer, and C Gairola. 1984. Effect of cigarette smoke exposure on lung and sperm enzymes in mice. Env. Mutagenesis. 6: 392-393.

28. Panda, B.B., G. Ficsor, and L.C. Ginsberg. 1985. Sperm enzyme test system to detect reprotoxic and genotoxic agents. Abstracts of the 10th Ann. Meet. of the Environmental Mutagen Society of India. Bombay, India. (Feb. 18-21).

29. Ficsor, G., L. Goldner, B. Panda, B. Imel, M. Burhans, and L. Ginsberg. 1985. Evidence for detection of transmitted induced mutation of mice by a computer- monitored open-field behavior test. Abstracts of the 4th International Conference on Environmental Mutagens. Stockholm, Sweden. (June 24-28). p. 197.

30. Ginsberg, L.C., W.C. Keller, B.M. Lewellyn, and G. Ficsor. 1985. Sperm enzyme activity as a measure of genotoxicity. Abstracts of the 4th International Conference on Environmental Mutagens. Stockholm, Sweden. (June 24-28). p. 200.

31. Ficsor, G. and L.C. Ginsberg. 1985. Sperm enzymes and lectins may be used for detection of agents which harm mammalian germ cells. Abstracts of the 13th Ann. Meet. of the Hungarian Biophysics Society. Debrecen, Hungary. (July 3-5).

32. Grams-Hall, K., C. McIntire and G. Ficsor. Cigarette smoke and vitamin E Alteratiosn in mouse testes. 90th Ann. Meet. MI. Acad. Sci., Arts, & Let., Mount Pleasant, MI, March 14-18, 1986.

33. Panda, B., L. Goldner, G. Ficsor, and L.C. Ginsberg. 1986. Behavior testing of transmitted induced mutations in mice. Abstracts of the 11th Ann. Meet. of the Environmental Mutagen Society of India. Madras, India.(Feb. 20-24).p.1.

34. Ginsberg, L.C., L. McKay, L. Hacker, and G. Ficsor. 1986. Lectin binding to sperm as a method for detection of mutations. Env. Mutagenesis. 8: 30.

35. McKay, L.A., L.C. Ginsberg, and G. Ficsor. The detection of germ cell mutation with lectins in ICR mice. 90th Ann. Meet. MI. Acad. Sci., Arts, & Let., Mount Pleasant, MI., March 14-15, 1986.

36. Glatt, K., A. Sweet, T. Boyle and G. Ficsor. Saccharomyces cerevisiae XD83: A new strain for detecting mutagenic agents. Ann. Meet. Michigan Chapter of the Society of Toxicology, Kalamazoo, MI, May 23, 1986.

37. Goldner, L., B.B. Panda and G. Ficsor. Motor coordination end-points for detection of mutations in the F1 progeny of ethyl methanesul fonate-treated male mice.23 Ann. Meet. Michigan Chapter of the Society of Toxicology, Kalamazoo, MI, May 23, 1986.

38. Ginsberg, L.C. and G. Ficsor. Sperm enzyme activity as a measure of reproductive toxicity. Ann. Meet. Michigan Chapter of the Socieyt of Toxicology. Kalamazoo, MI., May 23, 1986.

39. Ficsor, G., L.C. Ginsberg and M.S. Holm. Sperm enzyme activity and lectin binding as a measure of germ cell damage in mice. Abstract of contributed poster at the Symposium on "Role of Biomarkers in Reproductive and Developmental Toxicology". Natl. Acad. Sci., Washington, D.C., Jan 12-13, 1987.

40. Jeromin, J.S., S. Fuller, G. Ficsor, R. Beyer and F.C. Janca. Cervical cancer risk evaluation by acetic acid, Pap and human papilloma virus (HPV) nucleic acid hybridization tests. 92nd Ann. Meet. Mi. Acad. Sci. Arts and Let., Grand Rapids, MI, March 17-18, 1989.

41. Sharma, K., G. Ficsor and G.D. Shimer. Comparison of sister chromatid exchange (SCE) in Chinese hamster ovary (CHO) cells grown in serum-supplemented and serum- free media. Ibid.

42. Ficsor, G., S. Houtman, J.F. Klepetka, P.K. Andrus, G.D. Shimer and L.C. Ginsberg. In vitro amplification of specific DNA sequences. Ibid.

43. Jeromin, J.L. and G. Ficsor. 1988. Synthesis of human papillomavirus DNA probes using biotin. Abstracts of the 4th Int. Congr. Cell Biol. Montreal, Canada.

44. Ficsor, G., J.L. Jeromin, S.K. Fuller, and R.D. Beyer. 1988. Detection and typing of cervical human papilloma viruses with DNA/RNA hybridization. Abstracts of the 16th Int. Congr. Genet. Toronto, Canada.

45. Safron, A., K. Rank, L. Beuving and G. Ficsor. Visualization of polymerase chain reaction-amplified genomic mouse DNA by electron microscopy. 93rd Ann. Meet. MI. Acad. Sci. Arts and Let., Albion College, Albion, MI, March, 1988.

46. Ficsor, G., L.C. Ginsberg, J.R. Klepetka and T.P. McManus. Detection of gene mutations in mouse sperm with polymerase chain reaction (PCR). Env. Mol. Mutagen. 15:60, 1989.

47. Ficsor, G., T.P. McManus, J.F. Klepetka and L.C. Ginsberg. Mutation detection in mammalian sperm without progeny testing: Selection of mutant DNA. Env. Mol. Mutagen. Vol. 15, Suppl. 17, p. 19, 1990.

48. Safron, A.D., K.B. Rank, L. Beuving and G. Ficsor. Mutation detection in mammalian sperm without progeny testing: Visualization of polymerase chain reaction (PCR)-amplified genomic mouse DNA by electron microscopy. Env. Mol. Mutagen. Vol. 15, Suppl. 17, p. 15, 1990.

49. Ficsor, G., T.P. McManus, K. Rank and L.C. Ginsberg. Mutation detection in mammalian sperm without progeny testing: Preparation of pure mouse sperm DNA. Env. Mol. Mutagen. Vol. 17, Suppl. 19, p. 25, 1991.

50. Sharma, K., G. Ficsor and D. Milanwoski. Cytotoxic effect of mitomycin C on Chinese hamster ovary cells in serum-supplemented and almost serum-free media. 94th Ann. Meet. MI. Acad. Sci. Arts and Let., Eastern Michigan University, Ypsilanti, MI, March 1991.

51. Ficsor, G., T.P. McManus, K. Rank and L.C. Beuving. Mutation detection in mammalian sperm without progeny testing: Preparation of pure mouse sperm DNA. SOT Mich. Chapter Ann. Meet., Novi, MI. May 3, 1991.

52. Ficsor, G., J.T. Goodwin, W.A. Latack, J.A. Cornell. Environmentally induced germ cell mutations: Can they be detected? Michigan Academy, Mt. Pleasant, 1992.

53. Ficsor, G., J.T. Goodwin, J. Hinders-Leon, K. Rank, L.C. Ginsberg. Mutation detection in mammalian sperm without progeny testing: An in vitro model for method development. Env. Mol. Mutagenesis, Vol. 21, Suppl. 22, p.19, 1993.

54. Ficsor, G., J.T. Goodwin, B. Young, J.E. Hinders-Leon, W.A. Latack. Detection of mutations without cellular selection. Mich. Academician 25:292, 1993.

55. Higgins, M.J., C.S. Aaron, T.W. Petry, G. Ficsor and S.B. Friedman. The effect of pre- treatment with phenobarbital on the production of micronuclei in mice treated with monocrotaline. Mich. Academician 25: 343-4, 1994.

56. Higgins, M.J., G. Ficsor, C.S. Aaron, T.W. Petrey, R.L. Yu, S.B. Friedman. 1995. Micronuclei in mice treated with and without phenobarbital treatment. Env. Mol. Mutagenesis 25: suppl 25: 23.

 

57. Ficsor, G., S. Blazina, and C. Krause. 1996. Cadmium enhances the clastogenicity of cyclophosphamide in mice. Environment. Mol. Mutagen. 27(Suppl. 27):22.

58. Block, K. and G. Ficsor. 1996. Sixty Hz electro magenetic field decreases the clastogenicity of cyclophosphamide in mice. Ibid. p. 9.

59. Lentz, S. J., G. Ficsor, M. Varrichio and B. Tu. 1997. Detection of brachypodism inversions in mice using unidirectional primer PCR. Environment. Mol. Mutagen. 29(Suppl. 28):29.

60. Pandurangarao, V. L., S. Blazina, R. Bherje, A. Sandor, T. Nyirenda, S. Dent and G. Ficsor. 1997. Cadmium chloride strongly enhances cyclophosphamide-induced chromosome aberrations in mouse bone marrow cells. Ibid. P. 40.

61. Ficsor, G., D. Odziana, S. G. Smith and D. E. Findley. 1997. Cooperative learning in a large-enrollment introductory science course. Proceedings of The 27th Conference of the International Society for Exploring Teaching Alternatives, October 16-18, 1997, Frederickton, New Brunswick, Canada. In press.

  1. Ficsor, G. And D. Odziana. Individual responsibility is key to success for cooperative learning in a science course. Proceedings of The 28th Conference of the International Society for Exploring Teaching Alternatives, October 15-17, 1998. Coca Beech, FL
  2. Green, K. and Gyula Ficsor. Cadmium toxicity and mutagenicity in excision repair

deficient and proficient strains of Salmonella typhimurium. Annual Research Conference for minority students. Program book p. 182. New Orleans, LA. Nov. 13-18, 2002

 

PUBLISHED ARTICLES

1. Ficsor, G. 1962. Chemical treatment of seeds heterozygous for Wd and YG2. Maize Genetics Coop. News Letter. 36: 57-59.

2. Neuffer, M.G. and G. Ficsor. 1963. Mutagenic action of ethyl methanesulfonate in maize. Science. 139: 1296-1297.

3. Ficsor, G. 1963. Mutants recovered in the selfed progeny of chemically and x-ray treated seeds. Maize Genetics Coop. News Letter. 37: 102-104.

4. Ficsor, G. 1966. The nature of expression of EMS-, DES-, X-rays-, and UV-induced mutations in Zea mays Symposium on the mutational process, Prague: Mechanism of mutation and inducing factors. 163-168.

5. Ficsor, G. 1966. Chemical mutagenesis in Zea mays. Dissertation Abstr. 27(6): 1728B.

6. Ficsor, G. 1967. Chemical treatment of pollen in vivo by plastic bag method. Maize Genetics Coop. News Letter. 41: 141-142.

7. Ficsor, G. 1968. Graphic presentation of meiosis--An example of active student participation in learning. Mich. Sci. Teachers. Bull. 15: 13-14.

8. Ficsor, G. and E. Muthiani. 1971. A microbial assay for detecting chemical mutagens in tissue homogenates. Mutation Res. 12: 335-337.

9. Ficsor, G., R. Beyer, F.C. Janca, and D.M. Zimmer. 1971. An organ specific host- mediated microbial assay to detect chemical mutagens in vivo: demonstration of mutagenic action in rat testes following streptozotocin treatment. Mutation Res. 13: 283-287.

10. Ficsor, G. and G.M. Nii LoPiccolo. 1972. Survey of pesticides for mutagenicity by the bacterial plate assay method. Newsletter of the Environmental Mutagen Society. No. 6, pp. 6-8.

11. Ficsor, G., R.I. Zuberi, T. Suami, and T. Machinami. 1974. Differential mutagenicity of streptozotocin analogs of the carbohydrate moiety. Chemico-Biol. Interactions. 8: 395-402.

12. Ficsor, G., S. Bordas, S.M. Wade, E. Muthiani, G.F. Wertz, and D.M. Zimmer. 1977. Mammalian host- and fluid-mediated mutagenicity assays of captan and streptozotocin in Salmonella typhimurium. Mutation Res. 48: 1-16.

13. Maier, P., D.B. Feldman, and G. Ficsor. 1978. Host mediated assay in Rhesus monkey (Macaca mulatta): Mutagenicity of mitomycin C. Mutation Res. 57: 91-95.

14. Michelmann, H.W., P. Maier, G. Ficsor, and D.B. Feldman. 1978. Bone marrow and lymphocyte cytogenetics of Rhesus monkeys (Macaca mulatta) treated with the clastogen mitomycin C. Mutation Res. 57: 77-84.

15. Fry, S.M. and G. Ficsor. 1978. Cytogenetic test of captan in mouse bone marrow. Mutation Res. 58: 111-114.

16. Ficsor, G., S. Bordas, and S. Stewart. 1978. Mutagenecity testing of benomyl, methyl-2- bezimidazole carbamate, streptozotocin and N-methyl-N1-nitro-N- nitrosoguanidine in Salmonella typhimurium in vitro and in rodent hostmediated assays. Mutation Res. 51: 151-164.

17. Wertz, G.F. and G. Ficsor. 1978. Cytogenetic and teratongenic test of Firemaster (Polybrominate biphenyls) in rodents. Env. Health Persp. 23: 129-132.

18. Ficsor, G., H.V. Malling, H.W. Michelmann, D.B. Feldman, and S.M. Fry. 1979. Rhesus monkey (Macaca mulatta) model in genetic toxicology: Mitomycin C clastofenecity in germ cells. Mutation Res. 59: 37-43.

19. Ficsor, G. and L.C. Ginsberg. 1980. The effect of hydroxyurea and mitomycin C on sperm motility in mice. Mutation Res. 70: 383-387.

20. Ginsberg, L.C., S.C. Johnson, N. Salama, and G. Ficsor. 1981. Acrosomal proteolytic assay for detection of mutagens in mammals. Mutation Res. 91: 413-418.

21. Ficsor, G. and O.A. Elansari. 1981. Mitomycin C- and streptozotocin-induced heritable motility and numerical sperm variants in mice. Mutation Res. 90: 287-295.

22. Ficsor, G., N.M. Salama, K. Block, C. McIntire, and L.C. Ginsberg. 1982. Germ cell specific decrease of acrosomal proteolytic activity, sperm motility, and number in mitomycin C-treated mice. Teratog. Carcinog. Mutagen. 2: 13-18.

23. Ficsor, G., S.D. Ufkes, and P. Ehardt. In press. Saccharin: Lack of chromosome damage in mouse bone marrow cells. Fd. Cosmet. Toxicol.

24. Legator, M.S., E. Bueding, R. Batzinger, T.H. Connor, E. Eisenstadt, M.G. Farrow, G. Ficsor, A. Hsie, J. Seed and R.S. Stafford. 1980. An evaluation of the host- mediated assay and body fluid analysis: A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutation Res. 98: 319-374.

25. Ficsor, G., L.C. Ginsberg, G.M. Oldford, R.E. Snoke, and R.W. Becker. 1983. Gelatin- substrate film technique for detection of acrosim in single mammalian sperm. Fertility and Sterility. 39: 548-552.

26. Rodriguez, M., B.B. Panda, and G. Ficsor. 1983. Testes weight reflect ethylnitrosourea- induced histopathology in mice. Toxicology Letters. 17: 77-80.

27. Ficsor, G., G.M. Oldford, K.R. Loughlin, K.H. Ely, B.B. Panda, J.L. DuBien, and L.C. Ginsberg. 1984. Comparison of sperm enzyme, motility and testes weight methods for detecting mitomycin C- and ethylnitrosourea-induced germ cell damage in mice. Environmental Mutagenesis. 6: 287-298.

28. Waibel, R., L.C. Ginsberg, and G. Ficsor. 1984. Cytochemical detection of hyaluronidase activity in single human and mouse sperm by an improved substrate film technique. J. Histochem. and Cytochem. 32: 63-66.

29. Waibel, R., G.M. Oldford, G. Ficsor, and L.C. Ginsberg. 1984. Histochemical evaluation of sodium aurothiomalate inhibition of mouse sperm enzymes. J. Reprod. Fertil. 70: 151-155.

30. Waibel, R., R. Granet, G. Ficsor, L. Ginsberg. 1985. Caproyl esterase from rat testes: Purification and action on cumulus cells. Gamete Res. 12: 75-84.

31. Holm, M.S., A.E. Berger, K. Swanson, G. Ficsor, and L.C. Ginsberg. 1987. Ethylnitrosourea treatment increase lectin binding to mouse germ cells. Toxicology. 46:281-294.

32. Panda, B.B., G. Ficsor, and L.C. Ginsberg. 1988. Sperm enzyme activity analysis in individual sperm for detection of heritable mutations in mammals. Experientia. 44: 253-254.

33. Ficsor, G., L. Goldner, and b.B. Panda. 1988. Comparison of behaviors for detection of heritable mutations in mammals. Teratog. Carcinog. Mutagen. 8: 153-160.

34. Ficsor, G., L.C. Ginsberg, and T.P. McManus. 1989. Gene mutation detection in mammalian sperm without progeny testing. In proceedings: Contrib. Hung. Progr. Nat. Tech. Sci. Symp., (Ed. T. Konkoly). pp. 159-163. Orszagos Muszaki Informacios Kozpont and Konyvtar, Budapest.

  1. Ficsor, G., S. Fuller, J.L. Jeromin, R.D. Beyer, and F.C. Janca. 1990. Enhancing cervica

cancer detection using nucleic acis hybridization and acetic acid tests. The Nurse Pract. 15: 26-30.

36. Ficsor, G., L.C. Ginsberg, J.F. Klepetka, T.P. McManus, F.C. Janca, A.D. Safron, and K.B. Rank. 1990. Detection of gene mutations in mouse sperm with polymerase chain reaction (PCR). Prog. in Clinic. Biol. Res., Vol. 340C. Mutation and the Env. Part C: Somatic and Heritable Mutation , Adduction, and Epidemiol. (M.L. Mendelsohn and R.J. Albertini, eds.). pp. 213-222. Wiley-Liss, Somerset, NJ.

37. Sharma, K., D. Milanowski and G. Ficsor. Growth of Chinese Hamster Ovary (CHO) cells in the presence of MMC in low-serum medium. Mutation Res., 264: 183- 186, 1991.

38. Rank, K., T.P. McManus, L.C. Ginsberg and G. Ficsor. Preparation of Mouse-sperm DNA for PCR. Mutation Res., 264: 67-69, 1991.

39. Higgins, M.J., G. Ficsor, C.S. Aaron, T.W. Petry, R.L. Yu and S. Friedman. Micromnuclei in mice treated with monocrotaline with and without phono- barbital pre-treatment. Environment & Molec. Mutagenesis. 26: 37-43, 1995.

40. Jorgens, E.B., G. Ficsor, D. Hargreave. 1995. Biology and environmental studies in changing the major. American Association of Colleges and Universities, Washington D.C., pp 19-20.

41. Lentz, S. J., M. Varrichio, S. G. Smith and G. Ficsor. 1997. Detection of low copy number inversions in mouse genomic DNA with unidirectional PCR primers. Environmental and Molecular Mutagenesis. 30:260-263.

 

 

MASTER DEGREE PROJECTS COMPLETED WITH Dr. FICSOR AS MAJOR ADVISOR

1. Nii Lo-Piccolo, Gayle M. Captan-induced reversions in bacteria. 1972.

2. Janca, Frank C. N-methyl-N1 -nitrosoguidine-induced dominant and recessive mutation in Zea mays. 1972.

3. Beyer, Roger D. The organ-specific mammalian host=mediated microbial mutagen assay (OSHMA). 1972.

4. Zimmer, David M. Characterization of streptozotocin-induced small colony phenotypes in bacteria. 1973.

5. Zuberi, Riaz, I. Relationship of chemical structure and mutagenic activity of streptozotocin and its analogs. 1973.

6. Fedesna, Nicholas, E. TEM mutagenicity in rat spermatocytes. 1975.

7. Wertz, Gary F. Cytogenetic test of Firemaster (PBB) in rodents. 1978.

8. Harbach, Philip R. The effect of Selenium on the alkylation of rat DNA by 14C-1, 2- dimethylhydrazine. 1980.

9. Salama, Nassr. Mammalian germinal genetic toxicology of chemicals in wide-spread human use. 1980.

10. Elansari, Othman. Mammalian somatic genetic toxicology of chemicals in wide-spread human use. 1980.

11. Oldford, Gregory M. Ethyl nitroso urea- and mitomycin C-induced loss of sperm enzyme activities in mice. 1983.

12. Rodriguez, Mildred. A histopathological study of the effect of ethyl nitroso urea on HA (ICR) mice testes. 1983.

13. Trozs, Randy J. Germinal clastogenicity of chemical carcinogens in mice. 1984.

14. Hacker, L. Cyclophosphamide and ethylnitrsourea-induced lectin variants in HA (ICR) mice.

15. Goldner, L. Ethylmethanesulfonate-induced motor variants in HA (ICR) mice. 1985.

16. Burhans, J. Ethylnitrosourea-induced motor variants in HA (ICR) mice. 1985.

17. Jeromin, J.L. Identification of human papilloma virus types in cervical cells by RNA/DNA hybridization. 1988.

18. Boyle, T.P. Cloning and sequencing of the Eco RII monomer fragment of satellite DNA from the mouse Mus musculus. 1989.

19. Poppe, S.M. Site-directed mutagenesis of the putative processing site or recombinant human immunodeficiency virus reverse transcriptase. 1990.

20. McManus, Terrance P. Generation of an addition mutation at the BstY1 restriction site in the mouse HPRT Exon 3 using PCR. 1991.

21. Goodwin, Jennifer T. Mutation detection in mammalian sperm without progeny testing: Generations of insertion and deletion mutations at the HinCII site of a 229 bp segment of the mouse PGK2 gene. 1992.

22. Higgins, Michael. Micronuclei in mice treated with monocrotaline. 1995.

23. Lentz, Susan. In vivo detection of very low copy mutations in mouse DNA. 1996

24. Lombard, Mark. Growth factors and cancer mechanisms in cell lines (Co-directed with David Rinehold, Deapartment of Chemicstry, Western Michigan University). 1996

25. Blazina, Stephanie. Cadmium enhancement of cyclophosphamide-induced DNA damage.

1998

26. Gould, Lisa. Suppressive effect of cadmium on cisplatin induced umu C gene expression in Salmonella typhimurium (TA 1535/ pSK 1002) 1999

 

UNDERGRADUATE RESEARCH PROJECTS COMLETED SINCE 1998

1. Jennifer Fuentes. Detection of mutations in mammals. Honors Thesi. Lee honorsa College, Western michigan university, kalamazoo, MI., 1998

2. Margaret Lincoln. Cadmium/cyclophosphamide genotoxicity in mice. Dean=s Research Assistantship.

3. Kari Haag, Cell mutations in Chernobyl clean-up workers: deletion patterns in the hprt gene. Honors Thesis. Lee Honors College, Western michigan university. 1998

 

Ph.D. PROJETS COMPLETED (SCIENCE EDUCATION) WITH Dr. FICSOR AS DISSERTATION ADVISOR

1. Sharma, Kamlesh. Sister chromatid exchange in human lymphocytes. 1981.

2. Block, Kevin. The clastogenic effects of cyclophosphamide and sixty hertz eletromagnetic field on bone marrow cells of CD-1 mice. 1997

POSTDOCTORAL ASSOCIATES/VISITING SCIENTISTS WORKING UNDER THE DIRECTION OF Dr. FICSOR

1. Bordas, Sandor, MD. Ames test and host-mediated assays. 1977. From Hungary.

2.` Panda, Brahma, PhD. Reproductive toxicology xenobiotics. 1981-1983. From India.

3. Robert Waibel, PhD. Sperm-based bioassays. 1982-1984. From Switzerland.

4. David Swenson, PhD. Synthesis of model carcinogens. 1987

5. Frank C. Janca, PhD. Human papilloma virus research. 1989-1991

6. Pandurangarao, Vijaya, MD. Enhancement of cyclophosphamide clastogenicity by cadmium. 1996

 

 

 

PUBLICATIONS OR PUBLISHED MEETING ABRACTS WITH UNDERGRADUATE (*) OR UNDERREPRESENTED MINORITY COAUTHOS (**)

Ficsor, G. and W.C. Beckman*. 1968. Mutagenic inactivation of EMS in water and in germinating maize kernels. Genetics. 60: 176-177.

Ficsor, G., F.C. Jaaca, and C. VanHook*. 1970. Tests for mutagenicity using nitrosoguanidine, DDT and Captan in maize. Newsletter of the Environmental Mutagen Society. No. 3.

Ginsberg, L.C., G.M. Oldford*, K.R. Loughlin*, and G. Ficsor. 1982. Biochemical and immunochemical analysis of single sperm in mice treated with mutagens. 13th Ann. Meet. Evn. Mut. Soc. Boston, MA. Env. Mutagenesis. 4: 319.

Ginsberg, L.C., G.M. Oldford, S. Shors*, S. Smith*, M. Burnhans, K. Ely*, and G. Ficsor. 1983. Evaluation of sperm enzyme activities in F1 progeny of male mice treated with mitomycin C or ethylnitrosourea. Env. Mutagenesis. 5: 497-498.

Panda, B., R. Waibel, G. Oldford*, K. Loughlin*, C. Ogbu**, K. Panda, G. Ficsor, and L.C. Ginsberg. 1983. Sperm enzyme and motility assays in mice to detect genotoxic and/or reprotoxic effects. Env. Mutagenesis. 5: 400-401.

Ficsor, G., B. Panda, R. Waibel, M. Burhans, G. Oldford*, K. Ely*, B. Imel A. Podraza, K. Loughlin* and L. Ginsberg. Detection of fertility and Genetic effects of chemical substances in male mice. 4th Mich Soc. Tox. Meeting, Ann Arbor, MI. March 13, 1983.

Ficsor, G., L.C. Ginsberg, S.P. Smith*, J.F. Pregenzer, and C Gairola. 1984. Effect of cigarette smoke exposure on lung and sperm enzymes in mice. Env. Mutagenesis 6: 392-393.

Ginsberg, L.C., L. McKay*, L. Hacker, and G. Ficsor. 1986. Lectin binding to sperm as a method for detection of mutations. Env. Mutagenesis. 8: 30.

McKay*, L.A., L.C. Ginsberg, and G. Ficsor. The detection of germ cell mutation with lectins in ICR mice. 90th Ann. Meet. MI. Acad. Sci., Arts, & Let., Mount Pleasant, MI., March 14- 15, 1986.

Glatt, K., A. Sweet*, T. Boyle and G. Ficsor. Saccharomyces cerevisiae XD83: A new strain for detecting mutagenic agents. Ann. Meet. Michigan Chapter of the Society of Toxicology, Kalamazoo, MI, May 23, 1986.

41.Sharma, K., G. Ficsor and G.D. Shimer*. Comparison of sister chromatid exchange (SCE) in Chinese hamster ovary (CHO) cells grown in serum- supplemented and serum- ree media. Ibid.

Ficsor, G., S. Houtman*, J.F. Klepetka*, P.K. Andrus*, G.D. Shimer* and L.C. Ginsberg. In vitro amplification of specific DNA sequences. Ibid.

Ficsor, G., L.C. Ginsberg, J.R. Klepetka and T.P. McManus. Detection of gene mutations in mouse sperm with polymerase chain reaction (PCR). Env. Mol. Mutagen. 15: 60, 1989.

Ficsor, G., T.P. McManus, J.F. Klepetka* and L.C. Ginsberg. Mutation detection in mammalian sperm without progeny testing: Selection of mutant DNA. Env. Mol. Mutagen. Vol. 15, Suppl. 17, p. 19, 1990.

Sharma, K., G. Ficsor and D. Milanwoski*. Cytotoxic effect of mitomycin C on Chinese hamster ovary cells in serum-supplemented and almost serum-free media. 94th Ann. Meet. MI. Acad. Sci. Arts and Let., Eastern Michigan University, Ypsilanti, MI, March 1991.

Ficsor, G., J.T. Goodwin, W.A. Latack*, J.A. Cornell. Environmentally induced germ cell mutations: Can they be detected? Michigan Academy, Mt. Pleasant, 1992.

Ficsor, G., J.T. Goodwin, J. Hinders-Leon*, K. Rank, L.C. Ginsberg. Mutation detection in mammalian sperm without progeny testing: An in vitro model for method development. Env. Mol. Mutagenesis, Vol. 21, Suppl. 22, p.19, 1993.

Ficsor, G., J.T. Goodwin, B. Young, J.E. Hinders-Leon*, W.A. Latack*. Detection of mutations without cellular selection. Mich. Academician 25:292, 1993.

Ficsor, G., S. Blazina, and C. Krause*. 1996. Cadmium enhances the clastogenicity of cyclophosphamide in mice. Environment. Mol. Mutagen. 27(Suppl. 27):22.

Lentz, S. J., G. Ficsor, M. Varrichio* and B. Tu*. 1997. Detection of brachypodism inversions in mice using unidirectional primer PCR. Environment. Mol. Mutagen. 29(Suppl. 28):29.

Pandurangarao, V. L., S. Blazina, R. Bherje*, A. Sandor, T. Nyirenda**, S. Dent* and G. Ficsor. 1997. Cadmium chloride strongly enhances cyclophosphamide-induced chromosome aberrations in mouse bone marrow cells. Ibid. P. 40.

Ficsor, G., D. Odziana, S. G. Smith* and D. E. Findley*. 1997. Cooperative learning in a large- enrollment introductory science course. Proceedings of The 27th Conference, International Society for Exploring Teaching Alternatives, October 16-18, 1997, Frederickton, New Brunswick, Canada. In press.

Green, K**. and Gyula Ficsor. Cadmium toxicity and mutagenicity in excision repair

deficient and proficient strains of Salmonella typhimurium. Annual Research Conference for minority students. Program book p. 182. New Orleans, LA. Nov. 13-18, 2002